Can Aggressive Intravenous Hydration Prevent Cisplatin-Induced Renal Dysfunction?

Does hydration prevent radiocontrast-induced acute renal failure?

15. Fagerudd JA, Tarnow I, Jacobsen P et al. Predisposition to 17. Chen JW, Jen SL, Lee WL et al. Differential glucose tolerance in dipper and nondipper essential hypertension. Diabetes Care essential hypertension and development of diabetic nephropathy in IDDM patients. Diabetes 1998; 47: 439–444 1998; 21: 1743–1748 18. Schernthaner G, Ritz E, Philipp Th, Bretzel R. Die Bedeutung 16. Strojek K...

Comment on Cisplatin-Induced Renal Impairment

Sumatriptan ameliorates renal injury induced by cisplatin in mice

Objective(s): Cisplatin (Cis) is an anticancer compound, which is used for the treatment of various cancers. Sumatriptan (Suma) is a selective agonist of 5-hydroxytryptamine 1B/1D (5HT1B/1D) receptor, which is prescribed for the management of migraine. It is well-established that Suma has anti-inflammatory and antioxidant properties. We have explored the protective effe...

Oxytocin alleviates cisplatin-induced renal damage in rats

Objective(s):The purpose of the present study was to investigate the protective effect of oxytocin on cisplatin (CP)-induced renal damage in rats. Materials and Methods: Fourteen adult Sprague Dawley rats, weighing 200 to 210, were administered by cisplatin (CP, 2 mg/kg/day) twice a week for five weeks. Then, they were randomly divided into two groups and treated with either saline (1 ml/kg/day...

The Effect of Hydration Therapy with and without Magnesium Sulfate on Prevention of Cisplatin-Induced Nephrotoxicity

Background: Cisplatin is an antineoplastic agent used to treat many malignancies; however, the main side effect of cisplatin is nephrotoxicity. The aim of this study was to evaluate the effect of hydration therapy with and without magnesium on prevention of cisplatin-induced nephrotoxicity. Methods: This retrospective study was performed on 46 patients with malignancy who were candidate to rec...